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Effect of Genetic Polymorphism on Capecitabine-Induced Toxicity in Egyptian Cancer Patients
Sponsor: Ain Shams University
Summary
The goal of this observational study is to study the effect of a single nucleotide polymorphism in the CES1 gene (rs2244613) on capecitabine-induced toxicity in Egyptian cancer patients. This study will help in understanding the interindividual variability in the CES1 gene and the effect of a single nucleotide polymorphism in this gene (rs2244613) on capecitabine-induced toxicity in participants already taking capecitabine-based chemotherapy as part of their regular medical care.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
80
Start Date
2024-04-01
Completion Date
2025-08
Last Updated
2025-01-09
Healthy Volunteers
No
Conditions
Interventions
Capecitabine-based chemotherapy
Participants receiving capecitabine in an oral dose of 1,000-1,250 mg/m2 twice daily for the first 14 days of each 21-day cycle.
Locations (1)
Department of Clinical Oncology, Faculty of Medicine, Menoufia University
Shibīn al Kawm, Menoufia, Egypt