Inclusion Criteria:
1. Male or female aged ≥18 and ≤65 years old.
2. Patients with unilateral Meniere's disease who meet the diagnostic criteria for Meniere's disease in the Guidelines for the Diagnosis and Treatment of Meniere's Disease (2017).
3. At least 3 episodes of vertigo caused by Meniere's disease within 6 months before enrollment.
4. Those who understand and voluntarily sign the informed consent.
Exclusion Criteria:
1. Patients who have had previous ear surgery for Meniere's disease.
2. People who suffer from vertigo caused by organic lesions of the external, middle or inner ear.
3. Patients with diseases that the investigators believe may limit the subjects' participation in this trial:
* patients with acute intracranial hematoma;
* patients with hypokalemia (serum potassium \< lower limit of normal) or severe dehydration (needing infusion, or hospitalization, or life-threatening, requiring emergency treatment);
* patients with acute pulmonary edema;
* patients with hypotension (systolic blood pressure \<90 mmHg and/or diastolic blood pressure \<60 mmHg during the screening period);
* patients with severe cardiovascular and cerebrovascular diseases: such as New York Heart Association grade III or IV heart failure, myocardial infarction or unstable angina pectoris within the last 6 months, severe heart failure, progressive multifocal leukoencephalopathy, hypertension that is difficult to control with drugs (systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥100 mmHg), etc.;
* patients with major diseases of other important organs that affect their participation in this study.
4. Patients who need to use diuretics other than trial drugs for a long time after enrollment.
5. Patients with any of the following conditions are known or found in laboratory tests:
* serum creatinine (Cr) level is not within the normal range;
* human immunodeficiency virus (HIV) test is positive or has acquired immunodeficiency syndrome (AIDS);
* active syphilis infection (positive Treponema pallidum antibody and positive non-specific syphilis antibody);
* active hepatitis, hepatitis B: HBsAg and/or HBcAb are positive and HBV-DNA \> 500 IU/mL or the lower limit of detection of the research center \[only when the lower limit of detection of the research center is higher than 500 IU/mL\]; hepatitis C: HCV antibody is positive and HCV-RNA is positive or greater than the upper limit of normal value.
6. Patients with known or suspected history of allergy to the investigational drug (isosorbide) and its excipients (sorbitol, lactic acid, saccharin sodium, propylparaben, butylparaben, orange flavor).
7. Those with a history of drug abuse or alcoholism within 6 months before enrollment.
8. Patients who have taken any prohibited drugs specified in this protocol for more than 1 week within 4 weeks before the first administration, including but not limited to vestibular suppressants (including antihistamines - promethazine, diphenhydramine, chlorpheniramine, etc., benzodiazepines - diazepam, lorazepam, clonazepam, etc., anticholinergics - scopolamine, atropine, glycopyrrolate, etc., and antidopamines - prochlorperazine, droperidol, etc.), betahistine, diuretics (including thiazide diuretics - hydrochlorothiazide, chlorthalidone, indapamide, indapamide sustained-release tablets, etc., loop diuretics - furosemide, torsemide, etc., potassium-sparing diuretics - amiloride, triamterene, etc.), glucocorticoids (including prednisone, methylprednisolone, betamethasone, beclomethasone propionate, prednisolone, hydrocortisone, dexamethasone, etc.).
9. Those who received intratympanic injection of gentamicin within the last year.
10. Patients who have received any other clinical trial drugs/devices within 30 days before the first dose.
11. Pregnant or lactating women, female patients or male patients' partners who plan to become pregnant during the study period and within 6 months after the last dose, and those who are unwilling to use a medically recognized effective contraceptive method (such as intrauterine contraceptive device or condom) during the trial.
12. Those who are judged by the researchers to be unsuitable for inclusion.
