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Summary
Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition. Herein, investigators propose to elucidate the interaction between colonic fermentation and insulin resistance in modulating metabolism in youth with obesity.
Official title: Pathogenic Mechanisms of Obesity and Its Cardiometabolic Complications
Key Details
Gender
All
Age Range
15 Years - 22 Years
Study Type
INTERVENTIONAL
Enrollment
55
Start Date
2025-11-13
Completion Date
2030-03-31
Last Updated
2026-01-28
Healthy Volunteers
No
Interventions
Lactulose Oral Product
Each arm will undergo a study to induce colonic fermentation through lactulose at the beginning and at the end of the 12 weeks.
Locations (1)
Yale University
New Haven, Connecticut, United States