Clinical Research Directory

Browse clinical research sites, groups, and studies.

Sites Groups Studies

Back to Studies

ACTIVE NOT RECRUITING

NCT06768996

Music, Social Attention, and Dementia

Sponsor: University of California, San Francisco

View on ClinicalTrials.gov

Summary

This is an exploratory mixed-methods control-treatment study to evaluate if participation in rhythmic musical activities improves social attention and connectedness in individuals living with mild to moderate bvFTD and AD, and their caregivers. Secondary objectives include evaluating the potential relationships between brain networks associated with rhythm production, social attention, and connectedness in these populations.

Official title: The Impact of a Caregiver-patient Music Intervention on Social Attention and Connectedness in Persons Living With bvFTD and AD

Key Details

Gender

All

Age Range

55 Years - 89 Years

Study Type

INTERVENTIONAL

Enrollment

Start Date

2025-01-10

Completion Date

2026-12-01

Last Updated

2025-12-03

Healthy Volunteers

Yes

Conditions

Frontotemporal Dementia Alzheimer Disease

Interventions

BEHAVIORAL

Synchronous Rhythm Production

The treatment group will take part in a dyad-based musical rhythm production activity facilitated by a trained musician. This activity will involve two rhythm conditions. The first condition requires tapping along to one pre-recorded audio track composed of an ensemble of Brazilian percussion instruments. The second condition requires tapping along with prerecorded audio tracks of rhythms progressively increasing in difficulty. Participants who indicate proficiency in learning to tap along in both conditions will be able to progress to more complex rhythms. All tapping data will be gathered through a Roland digital hand percussion controller.

BEHAVIORAL

Solo Rhythm Production

Participants randomized to the control condition will complete the same rhythm conditions to the same recorded audio tracks described in the experimental condition. However, they will not interchange their tapping with their caregiver. They will participate in the rhythm task as a solo producer.

Inclusion (patients) * Male or female ≥ 55 years of age living with bvFTD; or ≥ 70 years of age living with AD. * Documentation of a bvFTD or AD diagnosis as evidenced by one or more known clinical features. * Written informed consent obtained from subject. Inclusion (caregivers) * Male or female ≥ 55 years of age living without diagnosis of neurological or psychiatric disease. * Individual capable of independent execution of activities of daily living, including personal care and hygiene, dressing, eating, use of a toilet, and mobility. * Written informed consent. Exclusion (patients) * Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data. * community-dwelling individuals not living with bvFTD * community-dwelling individuals with normal cognitive functioning * Individuals living with Alzheimer's disease or related dementias (primary progressive aphasia, semantic variant FTD, Lewy body dementia, vascular dementia, Parkinson's disease, or mixed dementia) * Individuals with a score of 2 or higher on the CDR * Individuals with a history of neuropsychiatric illness that would interfere with performance (e.g., transient psych hx of depression okay, hx of schizophrenia will be excluded) or medicated depression to control symptoms. * Individuals with unstable (e.g., cancer other than basal cell skin) or chronic (e.g., severe diabetes) medical conditions * Individuals with MRI contraindications (e.g., pregnancy, claustrophobia, metal implants that are contraindicated for MRI) * Individuals with physical impairment(s) precluding motor response * Individuals with inability to walk two blocks without stopping * Individuals with hearing or vision deficits that will not allow for completion of testing; inability to hear conversation conducted at an average volume (\~60 dB) * Individuals who practice music making or production for at least 30-mins per week * This may include instrumental or vocal, writing or arranging, alone or in groups * Listening to music for more than 30-mins weekly will not exclude the individual from the study Exclusion (Caregivers) * Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data. * Community-dwelling individuals living with diagnosis of a neurological or psychiatric disease o Community-dwelling individuals with abnormal cognitive functioning * Individuals living with dementia * Individuals with a history of neuropsychiatric illness that would interfere with performance (e.g., transient psych hx of depression okay, hx of schizophrenia will be excluded) or medicated depression to control symptoms * Individuals with unstable (e.g., cancer other than basal cell carcinoma) or chronic (e.g., severe diabetes) medical conditions * Individuals with physical impairment(s) precluding motor control * Individuals with inability to walk two blocks without stopping * Individuals with hearing or vision deficits that will not allow for completion of testing; inability to hear conversation conducted at an average volume (\~60 dB) * Individuals who practice music making or production for at least 30-mins per week * This may include instrumental or vocal, writing or arranging, alone or in groups * Listening to music for more than 30-mins weekly will not exclude the individual from the study

Locations (1)

Sandler Neurosciences Center

San Francisco, California, United States