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Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study
Sponsor: Wake Forest University Health Sciences
Summary
Alcohol use disorder (AUD) is a complex chronic brain disease characterized by compulsive alcohol use, loss of control over drinking, and negative emotional states. Extensive research has identified the general neural circuitry underlying AUD. There is an exciting opportunity to intervene in AUD using neuromodulation. Transcranial magnetic stimulation (TMS) offers a non-invasive method to modulate brain activity, making it a promising tool for investigating, modulating, and potentially treating AUD. However, the precise effects of TMS on neural circuits involved in AUD and the mechanisms underlying these effects must first be understood. Magnetoencephalography (MEG) is a neuroimaging method that provides direct measurement of brain activity within neural circuits with high temporal resolution. Critically, MEG can measure brain activity in a wide range of frequencies that are consistent with those targeted by TMS. The goal of this proposal is therefore to collect preliminary and feasibility data to support a future NIH grant application that would use MEG to investigate TMS effects in individuals with AUD (iAUD).
Official title: An Investigation of TMS Effects Using Magnetoencephalography (MEG) Among Individuals With and Without Heavy Alcohol Use
Key Details
Gender
All
Age Range
21 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2025-03-21
Completion Date
2026-06-30
Last Updated
2026-02-24
Healthy Volunteers
Yes
Interventions
Sham iTBS
Participants will receive sham iTBS
Active iTBS
Participants will receive active iTBS
10 Hz TMS
Participant will receive 10 Hz TMS
1 Hz TMS
Participant will receive 1 Hz TMS
Locations (1)
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States