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RECRUITING
NCT06770556
NA

Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study

Sponsor: Wake Forest University Health Sciences

View on ClinicalTrials.gov

Summary

Alcohol use disorder (AUD) is a complex chronic brain disease characterized by compulsive alcohol use, loss of control over drinking, and negative emotional states. Extensive research has identified the general neural circuitry underlying AUD. There is an exciting opportunity to intervene in AUD using neuromodulation. Transcranial magnetic stimulation (TMS) offers a non-invasive method to modulate brain activity, making it a promising tool for investigating, modulating, and potentially treating AUD. However, the precise effects of TMS on neural circuits involved in AUD and the mechanisms underlying these effects must first be understood. Magnetoencephalography (MEG) is a neuroimaging method that provides direct measurement of brain activity within neural circuits with high temporal resolution. Critically, MEG can measure brain activity in a wide range of frequencies that are consistent with those targeted by TMS. The goal of this proposal is therefore to collect preliminary and feasibility data to support a future NIH grant application that would use MEG to investigate TMS effects in individuals with AUD (iAUD).

Official title: An Investigation of TMS Effects Using Magnetoencephalography (MEG) Among Individuals With and Without Heavy Alcohol Use

Key Details

Gender

All

Age Range

21 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

10

Start Date

2025-03-21

Completion Date

2026-06-30

Last Updated

2026-02-24

Healthy Volunteers

Yes

Interventions

DEVICE

Sham iTBS

Participants will receive sham iTBS

DEVICE

Active iTBS

Participants will receive active iTBS

DEVICE

10 Hz TMS

Participant will receive 10 Hz TMS

DEVICE

1 Hz TMS

Participant will receive 1 Hz TMS

Locations (1)

Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States