Clinical Research Directory

Inclusion Criteria: * 1- both sex 2- All patients diagnosed MS ( in recovery on DMT) according to the 2017-McDonalds criteria. 3- Pt with MS suffer from git and hepatic symptoms not explained by known cause as Hepatitis virus،metabolic disorders as Wilson . hemochromatosis,etc Drug induced , Alcohol , Git symptoms as dysphagia, vomiting,reflux 4- An informed consent will be obtained from all the patients, the study will be approved by ethical committee in faculty of Medicine Assiut University Exclusion Criteria :1-patients already diagnosed with other GIT disorders before diagnosis of MS 2\_ Presence of other disorder or on medications that may affect the neurological or GIT disorders. 3\_ Patients failed to commit to the follow up visits and regular MRI scans 4\_ Patients refused to sign the written informed consent Patients who will meet the inclusion and exclusion criteria will be assessed in the 1st visit by direct interview followed by clinical examination and neuropsychological assessments. Baseline MRI scans will be obtained at the first visit \-