Clinical Research Directory

Inclusion Criteria: 1. 18-75 (inclusive) years old; 2. 18.0 kg/m\^2 ≤ BMI ≤ 35.0 kg/m\^2 and ≥ 50 kg for men and ≥ 45 kg for women at screening; 3. Diagnosis of mild or moderate essential hypertension; 4. Office blood pressure measurements meet any of the following at the time of screening: ① Patients who have not used any antihypertensive medication for at least 4 weeks prior to screening, with an average office sitting blood pressure (average of 3 measurements) of 150 mmHg ≤ SBP \< 180 mmHg and DBP \< 110 mmHg; ② Patients who have been using a stable dose of one or two component of antihypertensive medications (including single agents, two-drug combination or two-component combinations) for at least 4 weeks prior to screening, and who, in the judgment of the clinician, can be switched to levlevamlodipine maleate tablets (2.5 mg/day) or valacyclovir capsules (80 mg/day), and whose mean office sitting blood pressure meets 140 mmHg ≤ SBP \< 180 mmHg and DBP \< 110 mmHg; 5. Prior to randomization, mean office sitting blood pressure meets 140 mmHg ≤ SBP \< 180 mmHg and DBP \< 110 mmHg; 6. Medication adherence between 80% and 120% (including borderline values) during the introductory period. Exclusion Criteria: 1. Rrefractory hypertension, hypertensive emergencies, hypertensive sub-emergencies and secondary hypertension; 2. Allergy (≥ 3 drug or food allergies) or known hypersensitivity to levamlodipine, levlevamlodipine, valsartan and related drugs (dihydropyridine calcium channel blockers, angiotensin II receptor blockers); 3. History of malignancy within the last 5 years (with the exception of cured basal cell carcinoma of the skin, limited squamous cell carcinoma of the skin, or cervical cancer in situ), or an underlying malignancy currently under evaluation; 4. Known or suspected symptomatic upright/postural hypotension ; 5. Uncontrolled diabetes mellitus; 6. Abnormal thyroid function; 7. Severe cardiovascular or cerebrovascular disease within 6 months prior to screening or randomization.