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Liver and Spleen Stiffness to Predict the Presence of Esaphageal Varices in Cirrhotic With Advanced HCC
Sponsor: Azienda Ospedaliero Universitaria Policlinico Modena
Summary
Elasto-HCC is a prospective, uncontrolled, multicenter observational study involving several hepatology centers in Italy. Patients with liver cirrhosis and advanced hepatocellular carcinoma (HCC) who will need to undergo systemic therapy will be enrolled. Patients in the first phase will undergo measurement of liver and spleen stiffness and upper endoscopic evaluation and will subsequently be followed for 12 months
Official title: Assessment of Liver and Spleen Stiffness Measurement (LSM/SSM) Accuracy in Predicting the Presence of Oesophageal Varices Needing Treatment in Cirrhotic Patients With Advanced Hepatocellular Carcinoma (HCC) Who Undergo Systemic Therapy
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2023-06-20
Completion Date
2025-10
Last Updated
2025-01-22
Healthy Volunteers
No
Interventions
Liver and Spleen stiffness measurement.
The use of spleen stiffness measurement to reduce unnecessary upper digestive endoscopies has never been evaluated in this patient setting.
Locations (12)
UOC Gastroenterologia, Azienda Ospedaliero-Universitaria Policlinico Bari
Bari, Italy, Italy
UOC Gastroenterologia, IRCCS Policlinico Sant'Orsola, Università di Bologna
Bologna, Italy, Italy
UOC Medicina interna, malattie epatobiliari e immunoallergologiche, IRCCS Policlinico Sant'Orsola, Università di Bologna
Bologna, Italy, Italy
UOC Semeiotica Medica, IRCCS Policlinico Sant'Orsola, Università di Bologna
Bologna, Italy, Italy
Programma Dipartimentale di I fascia, Malattie del Fegato e delle vie Biliari, Azienda Ospedaliera Universitaria - Federico II, Università degli Studi di Napoli Federico II, Napoli
Naples, Italy, Italy
Azienda Ospedaliera
Novara, Italy, Italy
UOC Clinica Medica 5 - Unit of Internal Medicine and Hepatology, Azienda Ospedale Università Padova,
Padova, Italy, Italy
UOC Centro Malattie Apparato Digerente (CEMAD, IRCCS Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore,
Roma, Italy, Italy
Dipartimento delle Scienze Mediche,Chirurgiche e Neuroscienze,UNISIEN
Siena, Italy, Italy
USD Liver Unit, Azienda Ospedaliera Universitaria Integrata Verona
Verona, Italy, Italy
UOC Gastroenterologia, Azienda Ospedaliera-Universitaria Policlinico di Modena
Modena, Italy
UOC Gastroenterologia, Azienda Ospedaliera-Universitaria Policlinico di Modena
Modena, Italy