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A Response Surface Analysis for the Interaction Between Ciprofol and Sevoflurane
Sponsor: Feng Gao
Summary
Intravenous and inhalation combined anesthesia is a commonly used method for maintaining general anesthesia in clinical practice. This study aims to explore the interaction between ciprofol and sevoflurane. By employing response surface methodology, we constructed a three-dimensional pharmacodynamic interaction surface for various dose combinations of ciprofol and sevoflurane. This approach allows us to determine the nature of the interaction between the two drugs at any given level, thereby providing a ciprofol understanding of the dose-response relationship when ciprofol and sevoflurane are used in combination. This knowledge will serve as a theoretical basis for rational drug administration during surgery.
Official title: A Response Surface Analysis for the Interaction Between Ciprofol and Sevoflurane During Anesthesia Induction
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2025-02-01
Completion Date
2025-12-31
Last Updated
2025-01-14
Healthy Volunteers
No
Conditions
Interventions
Sevoflurane 0 + different doses of ciprofol
Sevoflurane 0% combined with ciprofol 0.1, 0.2, 0.3, 0.4, 0.6mg/kg, respectively.
Sevoflurane 0.7% + different doses of ciprofol
Sevoflurane 0.7% combined with ciprofol 0.1, 0.2, 0.3, 0.4, 0.5mg/kg, respectively.
Sevoflurane 1.0% + different doses of ciprofol 0.05
Sevoflurane 1.0% combined with ciprofol 0.05, 0.1, 0.2, 0.3, 0.4mg/kg, respectively.
Sevoflurane 1.5% + differnet doses of ciprofol
Sevoflurane 1.5% combined with ciprofol 0.05, 0.1, 0.2, 0.3, 0.4mg/kg, respectively.
Sevoflurane 2.0% + different doses of ciprofol
Sevoflurane 2.0% combined with ciprofol 0.05, 0.1, 0.15, 0.2, 0.3mg/kg, respectively.
Sevoflurane 2.5% + different doses of ciprofol
Sevoflurane 2.5% combined with ciprofol 0.05, 0.1, 0.15, 0.2, 0.3mg/kg, respectively.
Ciprofol 0 + different end-expiratory concentration of sevoflurane
Ciprofol 0 combined with sevoflurane 0.7, 1.5, 2.0, 2.5, 3.5%, respectively.
Ciprofol 0.05mg/kg + different end-expiratory concentration of sevoflurane
Ciprofol 0.05 mg/kg combined with sevoflurane 0.7, 1.5, 2.0, 2.5, 3.5 %, respectively.
Ciprofol 0.1mg/kg + different end-expiratory concentration of sevoflurane
Ciprofol 0.1mg/kg combined with sevoflurane 0.5, 1.5, 2.0, 2.5, 3.0 %, respectively.
Ciprofol 0.2 mg/kg + different end-expiratory concentration of sevoflurane
Ciprofol 0.2 mg/kg combined with sevoflurane 0.5, 1.5, 2.0, 2.5, 3.0 %, respectively.
Ciprofol 0.3 mg/kg + different end-expiratory concentration of sevoflurane
Ciprofol 0.3 mg/kg combined with sevoflurane 0.5, 1.0, 1.5, 2.0, 2.5 %, respectively.
Ciprofol 0.4 mg/kg + different end-expiratory concentration of sevoflurane
Ciprofol 0.4 mg/kg combined with sevoflurane 0.5, 1.0, 1.5, 2.0, 2.5 %, respectively.