Clinical Research Directory

Inclusion Criteria: 1. Diagnoses of knee osteoarthritis by American College of Rheumatology (ACR) 2. Kellgren \& Lawrence classification 1-3 3. Knee pain on movement 40 to 90 mm Visual Analog Scale 4. Knee pain and related functional reduction for at least 1 month Exclusion Criteria: 1. Pregnant or nursing, or with the ability to become pregnant and not using an accepted form of birth control 2. Other causes of knee-related pain (e.g. hip OA, arterial insufficiency, radiculopathy etc) have been ruled out by physical examinations. 3. Knee surgery for KOA 4. Intra-articular steroid injection and/or oral steroid treatment within the last six months 5. Rheumatoid arthritis 6. Symptomatic OA in other joints (i.e. hip, hand) 7. Use of narcotics on the day of evaluation 8. Active malignancy 9. Uncontrolled diabetes mellitus 10. Neurological conditions: sciatica, neuropathy, multiple sclerosis 11. Other chronic pain conditions that may affect results: Fibromyalgia, back pain, hip pain 12. Has any photobiomodulation (low level laser) device at home or has previously used photobiomodulation for knee pain 13. Has known dermatological sensitivity to light 14. Enrolled in any other clinical trial within the last 6 weeks or enrollment in another clinical trial during participation in this trial.