Clinical Research Directory

Inclusion Criteria: * patients from the city of Valdivia, Chile, from Dental Health Service of the Base Hospital of Valdivia for the rehabilitation of their teeth with dental implants, * age between 30 and 70 years old, * regardless of sex, * complete medical history (such as sex, age and comorbidities) will be recorded. * patients requiring bone regeneration at the time of examination should have an atrophic bilateral mandible with poor bone available according to periodontal deseases classification behind tooth #3.3 or #4.3; with an edentulous alveolar ridge with a remaining bone height of ≤ 6 mm. Exclusion Criteria: * patients had previous dental implant surgeries, * with maxillary sinus pathologies or oral tissue lesions, * diseases that produce acute/chronic pain, * smokers of more than 5 cigarettes per day, * with excessive alcohol consumption (more than three times per week), * who suffer from any systemic disease whose surgical intervention is prohibited, for example: severe heart disease, congenital coagulation factor deficiency, dialysis, or malignant tumor in terminal phase, * patients with diabetes that is not well controlled or who have difficulty achieving an Hb ≥ 7 g/dL in a preoperative examination, * patients taking any antiplatelet or anticoagulant drug, * patients with a history of heart disease.