Clinical Research Directory

Inclusion Criteria: All Parts: • Volunteers in general good health. Part 3, ONLY: HAN CHINESE Participants: * Participant must be first- or second-generation Han Chinese of full Chinese parentage (both parents of Han Chinese descent), residing outside of China. Participants must be in general good health. * First-generation participants will have been born in China to two parents and four grandparents, who were also born in China, and are of full Chinese descent. * Second-generation participants born outside of China must have two parents and four grandparents born in China and are of full Chinese descent. OR JAPANESE Participants: * Participant must be first- or second-generation Japanese parentage (both parents of Japanese descent), residing outside of Japan. Participants must be in general good health. * First-generation participants will have been born in Japan to two parents and four grandparents born in Japan and are of full Japanese descent. * Second-generation participants born outside of Japan must have two parents and four grandparents born in Japan and are of full Japanese descent. Exclusion Criteria: * History of any clinically significant illness/infection/major febrile illness, hospitalization, or any surgical procedure within 30 days prior to the first dose of study drug. * Use of tobacco or nicotine-containing products within 180 days prior to the first dose of study drug. * History of clinically significant (per investigator's judgment) drug or alcohol abuse within the last 6 months.