Clinical Research Directory

Inclusion Criteria: 1. Willing and able to provide written informed consent (ICF) and any required privacy authorization before the start of the study. 2. Aged ≥18 years at the time of signing the written informed consent. 3. Diagnosed with hypertrophic cardiomyopathy (HCM) according to the 2023 Guideline for Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy, meeting the following criteria: 1. Left ventricular wall thickness ≥15 mm in any segment at end-diastole, as assessed by echocardiography or cardiac magnetic resonance imaging (MRI). 2. Left ventricular wall thickness ≥13 mm in individuals with a positive pathogenic gene test or those identified as members of a genetically affected family. 3. Exclusion of other cardiovascular diseases or systemic/metabolic diseases causing ventricular wall thickening. Exclusion Criteria: 1. Uncontrolled primary hypertension. 2. Moderate or severe aortic valve stenosis and/or primary mitral valve disease with severe mitral regurgitation. 3. Confirmed infiltrative or storage diseases with a phenotype resembling hypertrophic cardiomyopathy (e.g., Fabry disease, amyloidosis). 4. Expected life expectancy \<1 years. 5. Severe infections, liver failure, renal failure, or other life-threatening conditions.