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Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery
Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Summary
The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS). The main questions it aims to answer are: * Is the type 2 inflammation impacting the olfactory epithelium regeneration, leading to OD? * Does a treatment interfering with one of the major T2 inflammatory cytokines, have an impact on the mechanisms of OD in CRS? Participants will undergo olfactory testing and nasal brushing before and after 3 months of treatment.
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
140
Start Date
2023-05-22
Completion Date
2026-09-30
Last Updated
2025-01-15
Healthy Volunteers
Yes
Interventions
Nasal brushing of the olfactory cleft
Nasal brushing of the olfactory cleft
Smell testing
Smell testing using the Sniffin' Sticks Test
Locations (1)
Cliniques Universitaires Saint-Luc
Brussels, Belgium