Clinical Research Directory

Inclusion Criteria: * Clinical-instrumental diagnosis of chronic liver disease. * Indication for treatment of HCC with RFA using the Barcelona Clinic Liver Cancer (BCLC staging system) classification system19; * Performing hepatic or splenic elastography by transient method with Fibroscan® (Echosens, Paris, France) or ARFI method (ACUSON Sequoia Siemens). * Signature of informed consent Exclusion Criteria: * Age \< 18 years; * Diagnosis of hepatocholangiocarcinoma or other hepatic focal lesions other than hepatocellular carcinoma; * Previous history of liver transplantation (OLT) and/or liver resection for HCC in the previous two years; * Liver disease in decompensation (Child-Pugh C) at the time of informed consent or within three months prior to enrollment; * Patients with other severe and advanced diseases that may affect short-term mortality (e.g. further non-remission neoplasms, heart failure \>NYHA III, chronic renal failure in dialysis, pulmonary diseases dependent on home oxygen therapy).