Clinical Research Directory

Inclusion Criteria: * Age 18-65 years old； * Meet the 2022 Chronic Hepatitis B Guidelines definition of chronic HBV infection: HBsAg and/or HBVDNA positive \>6 months;； * Immune clearance period: HBeAg positive, HBVDNA positive, ALT\>40U/L; * Newly treated patients; * Willing to sign informed consent Exclusion Criteria: * Patients with HAV, HCV, HEV infection and autoimmune liver disease; Pregnant and lactating women and patients who plan to give birth in the near future; * Patients with cirrhosis or liver cancer indicated by imaging or liver hardness testing; * A history of serious heart disease, including unstable or uncontrolled heart disease within the last 6 months; * Have a mental illness or history of mental illness; * Have uncontrolled seizures; * Alcoholics or drug users who have not abstained; * Have uncontrolled diabetes, hypertension, thyroid disease, retinopathy, autoimmune disease, etc.