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Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery
Sponsor: Nanjing First Hospital, Nanjing Medical University
Summary
The aim of this clinical trial is to understand the effects of dexmedetomidine and esketamine on postoperative sleep in patients undergoing cardiac surgery. The main questions it aims to answer are: Does dexmedetomidine or esketamine prevent the development of postoperative sleep disturbances? Which one works better? The researchers compared dexmedetomidine and esketamine with saline (a drug-free solvent) to see if dexmedetomidine and esketamine prevented the development of postoperative sleep disturbances. Participants will: 1. Intraoperative continuous infusion of dexmedetomidine, esketamine or saline until the end of surgery 2. Postoperative sleep was assessed on the first and third postoperative days using a sleep rating scale
Key Details
Gender
All
Age Range
40 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
180
Start Date
2024-10-11
Completion Date
2025-09
Last Updated
2025-02-07
Healthy Volunteers
No
Interventions
Intraoperative infusion of dexmedetomidine
Intraoperative infusion of 0.3ug/kg/h dexmedetomidine
Intraoperative infusion of esketamine
Intraoperative infusion of 0.3mg/kg/h esketamine
Saline control
Intraoperative infusion of equal volumes of saline
Locations (2)
Nanjing First Hospital，Nanjing Medical University
Nanjing, Jiangsu, China
Nanjing First Hospital
Nanjing, Jiangsu, China