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Effect of Food-derived Active Components on Digestive Tract Health in Adults with Irritable Bowel Syndrome
Sponsor: Peking University
Summary
The goal of this clinical trial is to learn if Bifidobacterium. animalis subsp. Lactis A6 Strain or resveratrol to improve the symptoms of diarrhea-predominate irritable bowel syndromes (IBS-D). The main questions it aims to answer are: 1. Does Bifidobacterium animalis subsp.Lactis A6 Strain or resveratrol improve the symptoms of IBS-D. 2. What is the optimal intervention dose of Bifidobacterium. animalis subsp.Lactis A6 Strain or resveratrol to improve IBS-D Researchers will compare Bifidobacterium. animalis subsp.Lactis A6 Strain or resveratrol interventions to placebo (one look-alike sunbstance that contains no interventions substance) to see if Bifidobacterium. animalis subsp.Lactis A6 Strain or resveratrol relief the symptoms of patients with IBS-D. Participants will: 1. Take Bifidobacterium. animalis subsp.Lactis A6 Strain or resveratrol every day for 30 days. 2. Visit the clinic once every 15 days for checkups and tests.
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
180
Start Date
2025-02-28
Completion Date
2025-12-31
Last Updated
2025-01-16
Healthy Volunteers
No
Conditions
Interventions
Prebiotic_L
subject will receive a low-dosage (1\*10\^5) of Bifidobacterium. animalis subsp.Lactis A6 Strain
resveratrol_L
subject will receive a low-dosage (300mg/d) of resveratrol
Prebiotic_M
subject will receive a medium-dosage (1\*10\^8) of Bifidobacterium. animalis subsp.Lactis A6 Strain
Prebiotic_H
subjects will receive a high-dosage (1\*10\^10) of Bifidobacterium. animalis subsp.Lactis A6 Strain
resveratrol_H
subject will receive a low-dosage (600mg/d) of resveratrol
placebo_Bif
subjects will receive placebo (one look-alike sunbstance that contains no prebiotics)
placebo_resveratrol
subjects will receive placebo (one look-alike sunbstance that contains no resveratrol)
Locations (1)
Peking University
Beijing, Beijing Municipality, China