Clinical Research Directory

Inclusion Criteria: 1. Male or female subjects \> 18 years \< 75 of age. 2. ECOG performance status 0-1. 3. Histologically confirmed colorectal adenocarcinoma. 4. Imaging (CT or MRI) or pathological confirmation of liver metastasis. 5. Child-Pugh grade A liver function. 6. FLR/sTLV (standardized total liver volume) \< 30% (patients without underlying liver diseases)or \< 40% (patients with liver diseases, such as hepatic steatosis, cirrhosis, or liver damage after chemotherapy). 7. The indication of surgery is evaluated by a multidisciplinary team attended by hepatobiliary surgeons, oncologists, hepatologists and radiologists. Exclusion Criteria: 1. Patients with unresectable extrahepatic metastatic disease (except potentially resectable lung metastases) or primary tumor. 2. Patients with severe concomitant diseases who are intolerance of major liver surgery by the judgment of the surgeon. 3. Diagnosis of other malignant tumors within the past 5 years. 4. Intention to become pregnant during the course of the study. 5. Inability to comply with the study protocol. 6. Previous enrollment in the current study.