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RECRUITING
NCT06780241

Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

Sponsor: The Cleveland Clinic

View on ClinicalTrials.gov

Summary

This project aims to validate sex-specific biologic signatures associated with aortic valve disease developed in a large multicenter CMR registry, using unsupervised phenomapping. The aim to use standard and advanced CMR techniques (MRF, DTI, chemical exchange transfer, and radiomics analysis) is to determine advanced CMR predictors of reverse remodeling following aortic valve surgery and develop sex-specific thresholds for risk. Infrastructure developed by this study will enable development of an innovative, scalable, sex-specific precision medicine cardiovascular imaging pipeline to determine overall risk and treatment response.

Key Details

Gender

All

Age Range

18 Years - 90 Years

Study Type

OBSERVATIONAL

Enrollment

200

Start Date

2024-12-10

Completion Date

2030-12-31

Last Updated

2026-01-02

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

CMR

CMR (with contrast at baseline and non-contrast at follow-up)

OTHER

Quality of Life Questionnaire

Rapid Assessment of Physical Activity questionnaire and the Kansas City Cardiomyopathy Questionnaire

Locations (1)

Cleveland Clinic

Cleveland, Ohio, United States