Clinical Research Directory
Browse clinical research sites, groups, and studies.
Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease
Sponsor: The Cleveland Clinic
Summary
This project aims to validate sex-specific biologic signatures associated with aortic valve disease developed in a large multicenter CMR registry, using unsupervised phenomapping. The aim to use standard and advanced CMR techniques (MRF, DTI, chemical exchange transfer, and radiomics analysis) is to determine advanced CMR predictors of reverse remodeling following aortic valve surgery and develop sex-specific thresholds for risk. Infrastructure developed by this study will enable development of an innovative, scalable, sex-specific precision medicine cardiovascular imaging pipeline to determine overall risk and treatment response.
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2024-12-10
Completion Date
2030-12-31
Last Updated
2026-01-02
Healthy Volunteers
No
Interventions
CMR
CMR (with contrast at baseline and non-contrast at follow-up)
Quality of Life Questionnaire
Rapid Assessment of Physical Activity questionnaire and the Kansas City Cardiomyopathy Questionnaire
Locations (1)
Cleveland Clinic
Cleveland, Ohio, United States