Clinical Research Directory

Inclusion Criteria: 1. Able and willing to provide a written informed consent 2. Subjects requiring elective orthopedic surgery 3. Conform to the ASA Physical Status Classification Exclusion Criteria: 1. Subjects with a history of severe allergies 2. Subjects with nervous system disease 3. Subjects with a history of mental illness 4. Subjects with abnormal liver and renal function 5. Subjects with poorly controlled hypertensive or hypotensive 6. QTc：\>450ms（male），\>470ms（female） 7. Subjects who screened positive for substance abuse 8. History of cardiac dysrhythmias requiring anti-arrhythmia treatment(s) 9. The investigators determined that other conditions were inappropriate for participation in this clinical trial