Clinical Research Directory

Inclusion Criteria: * Women * Diagnosed with melasma based on clinical and Wood's lamp examination * 30-59 years old * Skin type IV or V Exclusion Criteria: * Plan to be pregnant and breastfeeding women during the study period ( 12 weeks) * using or have used hormonal contraception in the last 6 months, or plan to use hormonal contraception during the study period (12 weeks) * Using topical melasma treatments such as corticosteroids, tretinoin, hydroquinone, and other skin whitening or lightening treatments in at least the last 2 weeks. * Have used topical therapy for melasma i.e. triple combination cream for at least 3 months and showed no significant improvement. * Using systemic therapy for melasma, e.g. antioxidants, tranexamic acid in at least the last 4 weeks.\* * History of eppeeling, laser or mechanical abrasion on the face in the last 6 months.\* * Using photosensitizer drugs such as tetracycline, phenytoin, carbamazepine, and spironolactone in at least the last 4 weeks. * Having other skin complaints that may interfere with the evaluation of melasma such as post-inflammatory hyperpigmentation, Hori nevus, Ota nevus, pigmented contact dermatitis, and other pigmentation disorders. * Difficulty in adherence to treatment such as long distance from home, work schedules, and busy activities.