Clinical Research Directory

Inclusion Criteria: * Patient followed for myelodysplastic syndrome or myelofibrosis. * Patient with platelet count ≥50 giga/L at inclusion. * Patients with severe anemia and hemoglobin \<70 g/L at baseline. * Patient with intolerance or contraindication to oral or subcutaneous chelation therapy. * Ferritinemia \>1000 µg/L or hepatic iron concentration ≥7 mg/g or cardiac T2\* \<20 ms at inclusion. * Patient able to understand (French-speaking) and comply with protocol, having signed informed consent. Exclusion Criteria: * Patients with primary hemochromatosis (transferrin saturation coefficient CS-Tf \> 45%). * Patients with a contraindication to the use of MEX-CD1: weight \< 30 kg, iron deficiency. * Patients with a known allergy or contraindication to heparin or citrate. * Patients undergoing azacitidine or other chemotherapy (or considered as such) for myelodysplastic syndrome or myelofibrosis. * Patient who received treatment with luspatercept or erythropoietin (EPO) during the month prior to inclusion. * Patients with indications for allogeneic bone marrow transplantation. * Patients with a known allergy to shellfish (MEX-CD1 contains chitosan of animal origin) or to one of the other components of MEX-CD1. * Patients with a peripheral vascular access that is difficult to access or that needs to be preserved. * Patients participating in other interventional research that could interfere with the results of the study. * Patients under legal protection or unable to express their consent. * Patients under psychiatric care. * Patient deprived of liberty by judicial or administrative decision. * Pregnant or breast-feeding women.