Clinical Research Directory

Inclusion Criteria: * Patients aged \>=18 * Bilateral or unilateral knee pain attributed to knee osteoarthritis (KOA). For bilateral KOA patients, the more severe knee will be permitted inclusion to the registry * Grade 1-3 Osteoarthritis as diagnosed on standing weight-bearing knee radiographs per the Kellen-Lawrence Grading scale * Knee pain \>6 months refractory to conservative medical management (Nonsteroidal anti-inflammatory drugs, acetaminophen, etc.) * Not eligible for surgical knee replacement or patient's personal preference to undergo Genicular Artery Embolization (GAE) for reasons such as minimally invasiveness of GAE Exclusion Criteria: * Active malignancy * Active infection of the affected knee * Platelets \<50,000/uL, INR \>2.0 (unless on anticoagulation that can be reversed or performing radial/pedal access without reversal) * Corticosteroid injection of the affected knee within 3 months of enrollment * Rheumatoid arthritis or other seronegative arthropathy * Previous surgery (excluding arthroscopy) of the affected knee * Grade 4 per Kellgren-Lawrence Grading Scale of the affected knee * Pregnancy or expected pregnancy * Glomerular Filtration Rate (GFR) \<30 * Anaphylactic reaction to iodinated contrast * Moderate to severe pain in other lower limb joints * Body weight \>400 lbs. (prohibiting safe angiography) * Peripheral arterial disease of the treated extremity (Rutherford Grade 2 or greater)