Clinical Research Directory

Inclusion Criteria: * Adults consulting at the MICHEL JOUVET unit, CH Le Vinatier, Bron * Adults with a diagnosis of major depressive episode (DSM-V) and with a MADRS score ≥ 15 * Adults with a diagnosis of OSAS on ventilatory polygraphy or polysomnography (AASM 2017 criteria) requiring CPAP. Exclusion Criteria: * Refusal to participate. * Pregnant and breast-feeding women * Under guardianship or curatorship. * Unstable psychiatric or physical pathology (e.g., hypomania, high suicidal risk) considered incompatible with the study by the investigators. * Other psychiatric, neurologic or somatic conditions * Contraindication to light therapy: retinopathy, retinitis pigmentosa, diabetic retinopathy, macular degeneration, glaucoma, recent eye surgery (less than 3 months). patient wishing to choose a provider other than the protocol provider. * Patient wishing to choose a device other than SEFAM's S-BOX or a mask other than the nasal mask at the time of introduction. * Nasal obstruction. * Refusal to use actimetry, refusal to use light therapy, refusal to use CPAP.