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GDM: Insulin with or Without Metformin?
Sponsor: University of Virginia
Summary
This will be a randomized trial of patients with gestational diabetes who start hypoglycemic therapy with metformin but eventually require insulin. It will examine whether continuing metformin when adding insulin versus discontinuing metformin when insulin is added is beneficial. The investigators hypothesize that continuing metformin will reduce the needed insulin dosage and improve maternal and neonatal outcomes in these patients.
Official title: Gestational Diabetes Treatment: Should We Continue Metformin When Starting Insulin? a Randomized Control Trial
Key Details
Gender
FEMALE
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
130
Start Date
2024-12-12
Completion Date
2027-05-01
Last Updated
2025-01-17
Healthy Volunteers
No
Conditions
Interventions
Metformin + Insulin
Pregnant women who have have gestational diabetes and have uncontrolled blood sugar with metformin alone will stay on metformin and add insulin.
Insulin
Pregnant women who have have gestational diabetes and have uncontrolled blood sugar with metformin alone will stop on metformin and add insulin.
Locations (1)
University of Virginia
Charlottesville, Virginia, United States