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Study on the Sex-specific, Lipid- and Lipoprotein-lowering Effects of Berberine
Sponsor: The University of Hong Kong
Summary
The goal of this clinical trial is to learn if berberine works to affect lipids and lipoproteins in Chinese females aged 20 to 65 years with hyperlipidaemia. The goal also includes to examine the sex-specific effect of berberine on lipids and lipoproteins. Our previous HMRF-funded randomized trial in men and prior evidence suggests berberine affects sex hormones. Given the different sex hormone profiles in men and women, the main question it aims to answer is: • Does berberine have sex-specific lipid-modifying effects? Researchers will compare berberine to a placebo (a look-alike substance that contains no drug) to see if berberine works to affect lipids and lipoproteins. Participants will: * Take a baseline questionnaire * Take berberine or a placebo every day for 12 weeks * Take follow-up visits after 8 weeks and 12 weeks for blood sample collections and tests
Official title: Assessing the Sex-specific, Lipid- and Lipoprotein-lowering Effects of Berberine Using Randomized, Placebo-controlled, Double-masked Trial
Key Details
Gender
FEMALE
Age Range
20 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2024-08-01
Completion Date
2026-03
Last Updated
2025-01-20
Healthy Volunteers
No
Conditions
Interventions
Berberine
Participants will take purified berberine (500 mg orally twice a day) for 12 weeks.
Placebo
Participants will take placebo tablets, a look-alike substance that contains no drug, (500 mg orally twice a day) for 12 weeks.
Locations (1)
School of Public Health, The University of Hong Kong
Hong Kong, Hong Kong