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Fecal Microbiota Transplantation for the Prevention of Infectious Complications After Liver Transplantation
Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Summary
The increasing emergence and spread of MDRB represents a major public health problem, with higher mortality in patients experiencing infections. Cirrhotic patients listed for OLT and after OLT are at high risk of MDRB colonization or infection due to the large use of broad-spectrum antibiotics in the post-transplant setting. Therefore, effective decolonization strategies in this particular setting are urgently needed. The investigators hypothesize that heterologous FMT can reduce infections rates in the pre-and post- OLT setting by MDRB decolonization and restoration of a more physiological microbiome.
Official title: Efficacy and Safety of Fecal Microbiota Transplantation for the Prevention of Early-onset Infectious Complications After Orthotopic Liver Transplantation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
144
Start Date
2023-05-01
Completion Date
2026-05-31
Last Updated
2025-01-20
Healthy Volunteers
Yes
Conditions
Interventions
Fecal microbiota transplantation (FMT)
To assess if heterologous FMT is more effective than autologous FMT in reducing the rate of major infection episodes within 6-months after OLT.
Locations (1)
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy