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Evaluation of Combined Sensitising and Hypomethylating Therapy Outcomes in AML PDX
Sponsor: Clinical Hub for Interventional Research (CHOIR)
Summary
The goal of this observational study is to develop new ways to test new drug combinations to kill tumour cells, in patients with acute myeloid leukemia (AML). The main questions it aims to answer are: * Are there new ways to speed up discovery of better treatments for AML patients using AML cells from individual from patients in special mice that can accept human tissue? * Do these mice show treatment responses that are similar to the individual AML patient from whom cells were derived? Participants with AML who are taking standard of care treatment of venetoclax and azacitidine will be asked to donate blood and bone marrow samples for this study.
Official title: COSMOS-Avatar: Evaluation of Combined Sensitising and Hypomethylating Therapy Outcomes in AML PDX
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
25
Start Date
2025-06-06
Completion Date
2030-03
Last Updated
2025-12-08
Healthy Volunteers
No
Conditions
Locations (4)
Canberra Health Services
Canberra, Australian Capital Territory, Australia
Prince of Wales Hospital
Sydney, New South Wales, Australia
Royal North Shore Hospital
Sydney, New South Wales, Australia
Westmead Hospital
Westmead, New South Wales, Australia