Clinical Research Directory

Inclusion Criteria 1. Age ≥18 years, with no restriction on sex or ethnicity; 2. Diagnosis of primary hypertension, with no prior use of antihypertensive medication, and in the untreated state presenting with office systolic blood pressure (SBP) \<140 mmHg and diastolic blood pressure (DBP) ≥90 mmHg, as well as 24-hour ambulatory blood pressure monitoring (ABPM) showing SBP \<130 mmHg and DBP ≥80 mmHg; 3. Willingness to participate and provision of written informed consent. Exclusion Criteria 1. DBP ≥110 mmHg; 2. Secondary hypertension; 3. Requirement for antihypertensive or blood pressure-lowering medications due to comorbid conditions (e.g., SGLT2 inhibitors, GLP-1 receptor agonists); 4. Cardiac arrhythmias interfering with blood pressure measurement (e.g., atrial fibrillation); 5. Contraindications to RDN, including renal transplantation, renal insufficiency (eGFR \<45 mL/min/1.73 m²), renal artery anatomy unsuitable for the procedure (inability to access the renal vasculature; renal artery diameter \<4 mm or length \<20 mm; hemodynamically or anatomically significant renal artery abnormalities or stenosis; prior coronary or renal artery interventions including angioplasty or stenting), and severe hepatic impairment; 6. Contraindications to interventional procedures such as coagulopathy; 7. Pregnancy, planning pregnancy, or breastfeeding; 8. Life expectancy \<1 year; 9. Participation in another clinical trial.