Clinical Research Directory

Inclusion Criteria: * Male or female, age 18-40 * In good health as determined by OMSO (Office of Medical Support and Oversight) * Willing to refrain from exercise and caffeinated or alcoholic beverages for 12 hours before each testing session * Willing to refrain from antioxidant-rich foods, such as blueberries, pecans, and dark chocolate, 48 h before each testing session * Eumenorrheic females (menstrual cycle length between 24-35 days) or females taking oral contraceptives, or utilizing implantable contraception (e.g., intrauterine device) * Have supervisor approval if active-duty military or a federal employee at NSSC Exclusion Criteria: * History of cold injuries of any severity (e.g., frostbite, trench foot, chilblains) * Raynaud's syndrome * Cold-induced asthma/bronchospasm * Previous hand/finger injuries that impair dexterity and hand function * Metal hardware (plates/screws) in the forearms and hands * Smoke, vape, or use smokeless tobacco or other nicotine-containing products habitually (unless have quit \> 4 months prior) * Current use of medications (except for birth control) or dietary supplements that could alter cardiovascular, thermoregulatory, or vascular control (e.g., anti-hypertensives, statins) * History of disease of the gastrointestinal tract including (but not limited to) diverticulosis, diverticulitis and inflammatory bowel disease, peptic ulcer disease, Crohn's disease, ulcerative colitis; or previous gastrointestinal surgery * Have a history of renal disease including (but not limited to) chronic kidney disease, acute kidney injury, kidney stone disease, glomerular disease, or nephritis * Known allergies to medical adhesives * Known allergy to MitoQ * Difficulty swallowing pills * Heart, lung, kidney, muscle, or nerve disorder(s) * A planned MRI during the study or within 3 days after completing a cold test * Women who are pregnant, planning to become pregnant, or breastfeeding * Not willing to have small areas of skin on the body shaved (if deemed necessary for attachment of study instrumentation) * Have donated blood within 8 weeks of the study or plan to donate blood during the study * Lesions on a significant portion of the upper extremities due to skin pigmentation disorders (e.g., vitiligo, psoriasis)