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RECRUITING

NCT06785168

The Effect of Resistance Training on Sarcopenia in Older Heart Failure Patients

Sponsor: Kieu Nguyen Dang Phuong

View on ClinicalTrials.gov

Summary

The goal of study is to evaluate the effects of an eight-week machine-based resistance training program on managing sarcopenia in older outpatients with chronic heart failure (HF) at Military Hospital 175.

Official title: The Effects of Machined Based Resistance Training in Older Patients With Chronic Heart Failure With Sarcopenia

Key Details

Gender

All

Age Range

60 Years - Any

Study Type

INTERVENTIONAL

Enrollment

146

Start Date

2024-12-24

Completion Date

2027-12-31

Last Updated

2026-02-17

Healthy Volunteers

Conditions

Sarcopenia in Elderly Chronic Heart Failure

Interventions

OTHER

Machine-based Resistance Training

The participants will receive HF treatment as prescribed by cardiologists. If participants have any additional medical conditions, their existing medications or treatments should continue. They are also asked to maintain their usual physical activity, exercise routines, and dietary habits, without making changes outside of the study intervention. At the beginning, patients participating in resistance training should complete a pretest of one-repetition maximum (1-RM) to assess muscle strength, which will be used by a professional physical therapist to develop an individualized prescription. The specific movements are as follows: (1) leg press and (2) calf raise by Proxomed Compass 540 (Germany); (3) leg curl, (4) chest press, (5) push up, (6) seated row by HUR machine (US). During the 8 weeks, subjects will train 3 non-consecutive days/week with intensity 30%1-RM to 60% 1-RM, 3 sets/one excercise with 8-12 repetitions.

Inclusion Criteria: * Aged ≥ 60 years old * Meet the diagnostic criteria of 2019 AWGS2 sarcopenia, can be diagnosed once meeting (1) + (2) or (1) + (3) or (1) + (2) + (3): (1) Appendicular skeletal muscle mass (ASM): dual-energy X-ray absorptiometry (DXA) (male \<7.0 kg/m², female \<5.7 kg/m²). (2) Muscle strength: handgrip strength (male \<28.0 kg, female \<18.0 kg). (3) Physical performance: 6-meter walking speed \<1.0 m/s. * Meet the diagnostic criteria of heart failure following ESC 2021. * Clearly understand the content and purpose of the study and sign the informed consent form. Exclusion Criteria: There are contraindications for Exercise Testing in patients with stable heart failure according to ACSM 2022: * Early stage after acute coronary syndrome (within the first 2 days) * Unstable coronary artery disease * Decompensated heart failure * Acute venous thrombosis or recent arterial embolism (pulmonary or systemic) * Acute myocarditis, pericarditis, endocarditis * Aortic dissection of the valve * Severe symptomatic aortic stenosis * Acute systemic disease or fever * Uncontrolled or life-threatening atrial or ventricular arrhythmias (including new-onset atrial fibrillation or flutter) * Uncontrolled tachycardia (resting heart rate \> 120 beats per minute) * Third-degree AV block * Uncontrolled diabetes * Symptomatic orthostatic hypotension (\> 20 mmHg) * Gradually increasing fatigue during exercise or dyspnea at rest or with exertion within the past 3-5 days * Significant myocardial ischemia at low workloads \< 2 METs or 50W * Relative contraindications according to ACSM 2022: * Weight gain ≥ 1.8 kg in the past 1-3 days * Simultaneous use of continuous or intermittent Dobutamine * Decrease in blood pressure with exercise * NYHA IV heart failure * Complex ventricular arrhythmias at rest or with exertion * Resting heart rate ≥ 100 bpm when lying down * Comorbidities that limit exercise * Severe obstructive hypertrophic cardiomyopathy * Have participated in a cardiovascular rehabilitation program within the last 6 months * Do not agree to participate in the study

Locations (2)

Military Hospital 175

Ho Chi Minh City, Vietnam

University of Medicine and Pharmacy at Ho Chi Minh City