Clinical Research Directory

Inclusion Criteria: * Age of 18 years or older * Capable of understanding and signing informed consent * A diagnosis of HFpEF according to the HFA-PEFF diagnostic algorithm of the ESC or/and a high (90%) probability of HFpEF according to the H2FPEF score, i.e. a score of 6 or higher. Exclusion Criteria: * History of LVEF ≤40% * Scheduled for surgery or intervention for both coronary and non-coronary indication within 6 months of inclusion * Impaired renal function, defined as eGFR \< 20 mL/min/1.73 m2 (CKD-EPI) or requiring dialysis at the time of screening * Acute or chronic liver disease, defined by serum levels of transaminases or alkaline phosphatase more than three times the upper limit of normal at screening * COPD Gold stage IV * Congenital heart disease * Pregnancy * Coexistent condition with life expectancy of \<1 year * Unlikely to appear at all scheduled follow-up visits * Linguistic barrier