Clinical Research Directory

Inclusion Criteria: * patients with symptomatic irreversible pulpitis and symptomatic apical periodontitis * maxillary or mandibular single rooted teeth * systemically healthy patients * patients having pain score \< 8 Exclusion Criteria: * patients on preoperative analgesics or antibiotics within past 12 hours * teeth with calcified canals and previously treated teeth * tooth with immature apices or resorption * patients allergic to local anesthesia * pregnant or lactating mothers * patients who are immunocompromised .