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Clinical Impact of Non-invasive Neurally Adjusted Ventilatory Assist in Very Preterm Infants
Sponsor: Korea University Anam Hospital
Summary
This is a prospective observational study investigating the impact of NIV-NAVA on short-term clinical outcomes and long-term neurodevelopment in very preterm infants.
Key Details
Gender
All
Age Range
1 Hour - 48 Hours
Study Type
OBSERVATIONAL
Enrollment
80
Start Date
2025-01-20
Completion Date
2030-12-20
Last Updated
2025-06-17
Healthy Volunteers
No
Conditions
Interventions
Non-invasive NAVA
Initiate respiratory assist with NIV-NAVA within 48 hours. The setting of respiratory support will be adjusted based on clinical conditions of each subject. NIV-NAVA could be switched to nasal continuous airway pressure or high flow nasal cannula, and it also could be stopped after initial stabilization. In cases of respiratory distress syndrome, lung surfactant will be administered via the less invasive surfactant administration (LISA) method and avoid endotracheal intubation whenever possible. For who intubated in the delivery room, extubation with NIV-NAVA should be considered as soon as possible. Endotracheal intubation with invasive ventilation could be applied when clinical deteriorations happens.
Locations (2)
Seoul National Bundang Hospital NICU
Seongnam-si, Gyeonggi-do, South Korea
Korea University Anam Hospital, NICU
Seoul, South Korea