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Night-shift Work and Breast Cancer
Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Summary
Scientific evidence established about the effects of night work on health both in the short term (insomnia, excessive sleepiness, difficulty concentrating or lack of energy) and in the long term (moderately high risk of developing cardiovascular disease, type 2 diabetes, depression, cancer). In light of the scientific evidence, the IARC (International Agency for Research on Cancer) has listed night work as a probable human carcinogen (Group 2). With respect to current knowledge, the present study could provide valuable help in understanding the mechanisms by which circadian rhythm alteration acts at the genetic level in terms of promoting oncogenesis. Furthermore, by studying its association with other risk factors, understand whether there is a pattern of women more susceptible to its oncopromoting action.
Key Details
Gender
FEMALE
Age Range
20 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
6000
Start Date
2025-01-31
Completion Date
2025-12-31
Last Updated
2025-01-22
Healthy Volunteers
No
Conditions
Interventions
Questionnaire
All cases and controls will be contacted by telephone or e-mail and invited to participate in the study. Female workers who decide to join the study will be asked to go to their company's occupational health clinic where they will undergo administration of a questionnaire to investigate possible known and unknown risk factors for breast cancer
Blood samples for biomarker measurement
Women who give consent to undergo this phase of the study will be called back to the center and will be asked to provide a blood sample
Locations (2)
IRCCS Azienda Ospedaliero - Universitaria di Bologna, U.O. Medicina del Lavoro
Bologna, Italy
AOU G. Martino Messina U.O.S.D. Medicina del Lavoro
Messina, Italy