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Effectiveness and Safety of Zingiber Officinale Transdermal Patch for Acne Vulgaris; Study of Interleukin 1 and Skin Microbiome
Sponsor: Hasanuddin University
Summary
The goal of this clinical trial is to investigate the effectivity and safety of mild to moderate acne vulgaris therapy using Zingiber officinale 5 % transdermal patch. Researcher will compare both half faces (split face); one side as treatment side where patch is used, and another side as control. Patient will be asked to apply tretinoin 0,025% cream nightly. After applying tretinoin 0,025% on whole face, patient will be asked to apply patch on a pustule on one half face, and no patch will be used on another half face. Total lesion count will be assessed before treatment and 21 days after treatment. Specimen for skin microbiome and interleukin examination will be collected before and 21 days after treatment.
Key Details
Gender
FEMALE
Age Range
15 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
26
Start Date
2024-11-03
Completion Date
2025-10-31
Last Updated
2025-09-15
Healthy Volunteers
No
Conditions
Interventions
tretinoin 0.025% + Z. officinale patch
Material used for patch formulation were 3,15 grams of polyvinyl alcohol, 4,2 grams of polyvinyl pyrrolidone, 12,6 ml distilled water, and 1,05 grams of Z. officinale extract.
tretinoin 0.025% cream
no Z. officinale patch applied after tretinoin 0.025% application
Locations (1)
Doctoral Programme, Faculty of Medicine, Hasanuddin University
Makassar, South Sulawesi, Indonesia