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Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer
Sponsor: Regeneron Pharmaceuticals
Summary
This study is researching an experimental drug called ubamatamab, also referred to as "study drug". The study is focused on patients who have advanced ovarian cancer. The aim of the study is to see how safe, tolerable, and effective the study drug is on its own and in combination with other anti-cancer drugs (bevacizumab, cemiplimab, fianlimab and a standard chemotherapy drug, pegylated liposomal doxorubicin \[PLD\]), referred to as "combination drugs'. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug and its experimental combinations * How much study drug and fianlimab is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects) and its combinations
Official title: Multi-Arm Phase 2 Platform Study of Ubamatamab (REGN4018; MUC16×CD3 Bispecific Antibody) With or Without Additional Agents in Platinum-Resistant Ovarian Cancer
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
220
Start Date
2025-05-28
Completion Date
2028-10-30
Last Updated
2026-04-08
Healthy Volunteers
No
Interventions
Ubamatamab
Administered per the protocol
Bevacizumab
Administered per the protocol
Cemiplimab
Administered per the protocol
Fianlimab
Administered per the protocol
PLD
Administered per the protocol
Sarilumab
Administered per the protocol
Locations (50)
The University of Alabama at Birmingham
Birmingham, Alabama, United States
UC San Diego Health
La Jolla, California, United States
Cedars Sinai Medical Center
Los Angeles, California, United States
Mayo Clinic Jacksonville
Jacksonville, Florida, United States
University of Miami Sylvester Comprehensive Cancer Center
Miami, Florida, United States
Advent Health Cancer Institute
Orlando, Florida, United States
Tampa General Hospital Cancer Institute
Tampa, Florida, United States
University of Chicago
Chicago, Illinois, United States
The University of Kansas Cancer Center
Westwood, Kansas, United States
Norton Cancer Institute, St. Matthews Clinic
Louisville, Kentucky, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Karmanos Cancer Institute
Detroit, Michigan, United States
The Ohio State University Comprehensive Cancer Center
Hilliard, Ohio, United States
Providence Cancer Institute
Portland, Oregon, United States
West Penn Hospital of Allegheny Health Network
Pittsburgh, Pennsylvania, United States
Avera Cancer Institute Sioux Falls
Sioux Falls, South Dakota, United States
UT Southwestern Medical Center
Dallas, Texas, United States
Swedish Cancer Institute
Seattle, Washington, United States
University of Wisconsin
Madison, Wisconsin, United States
Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Research Institute - McGill University Health Centre
Montreal, Quebec, Canada
Centre Hospitalier Universitaire (CHU) de Quebec - Universite Laval
Québec, Canada
National Cancer Center
Gyeonggi-do, Gyeonggi-do, South Korea
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
Gachon University Gil Medical Center
Incheon, Seoul, South Korea
Keimyung University Dongsan Hospital
Daegu, South Korea
Severance Hospital Yonsei University Health System
Seoul, South Korea
Asan Medical Center, Univ. of Ulsan
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Gangnam Severance Hospital
Seoul, South Korea
Seoul National University Hospital
Seoul, South Korea
Korea University Guro Hospital
Seoul, South Korea
Changhua Christian Hospital
Changhua, Changhua City, Taiwan
Chi Mei Medical Center
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Mackay Memorial Hospital
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Tri-Service General Hospital
Taipei, Taiwan
Taipei Municipal Wan Fang Hospital
Taipei, Taiwan
Medicalpark Seyhan Hospital
Seyhan, Adana, Turkey (Türkiye)
Hacettepe University
Altındağ, Ankara, Turkey (Türkiye)
Medipol University Hospital
Istanbul, Bagcilar, Turkey (Türkiye)
Gaziantep Medicalpoint Hospital
Gaziantep, Sehitkamil, Turkey (Türkiye)
Baskent University
Adana, Turkey (Türkiye)
Sbu Doctor Abdurrahman Yurtaslan Ankara Onkoloji Suam
Ankara, Turkey (Türkiye)
Ankara Bilkent City Hospital
Ankara, Turkey (Türkiye)
Memorial Ankara Hospital
Ankara, Turkey (Türkiye)
Cerrahpasa Medical Faculty At Istanbul University Cerrahpasa
Istanbul, Turkey (Türkiye)
Izmir Ekonomi Universitesi (IEU) Medical Point Izmir Hastanesi (Izmir Economy University Medical Point Izmir Hospital)
Izmir, Turkey (Türkiye)
Sakarya University - Education and Research Hospital
Sakarya, Turkey (Türkiye)