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A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring
Sponsor: Janssen Research & Development, LLC
Summary
The purpose of this study is to collect long-term safety data in participants with cancers including acute myeloid leukemia, non-Hodgkin lymphoma, myelodysplastic syndrome, chronic lymphocytic leukemia (type of cancer of the blood and bone marrow in which the bone marrow makes a large number of abnormal blood cells) and advanced solid tumors and metastatic castration-resistant prostate cancer (mCRPC).
Official title: An Open Label, Rollover Platform Study for Continued Study Treatment and Ongoing Safety Monitoring
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2024-12-30
Completion Date
2028-10-30
Last Updated
2026-04-07
Healthy Volunteers
No
Conditions
Interventions
JNJ-75348780
Participants from the parent study (75348780LYM1001 \[NCT04540796\]) who are deriving benefit from study treatment will continue to receive subcutaneous JNJ-75348780.
JNJ-67856633
Participants from the parent studies (64264681LYM1002 \[NCT04657224\], 67856633LYM1002 \[NCT04876092\] and 67856633LYM1001 \[NCT03900598\]) who are deriving benefit from study treatment will continue to receive JNJ-67856633 orally.
JNJ-54179060
Participants from the parent study (67856633LYM1002 \[NCT04876092\]) who are deriving benefit from study treatment will continue to receive JNJ-54179060 orally.
JNJ-64264681
Participants from the parent studies (64264681LYM1001 \[NCT04210219\], 64264681LYM1002 \[NCT04657224\]) who are deriving benefit from study treatment will continue to receive JNJ-64264681 orally.
JNJ-74856665
Participants from the parent study (74856665AML1001 \[NCT04609826\]) who are deriving benefit from study treatment will continue to receive JNJ-74856665 orally.
JNJ-70218902
Participants from the parent study (70218902EDI1001 \[NCT04397276\]) who are deriving benefit from study treatment will continue to receive JNJ-70218902 orally.
JNJ-64619178
Participants from the parent study (64619178EDI1001 \[NCT03573310\]) who are deriving benefit from study treatment will continue to receive JNJ-64619178 orally.
JNJ-80948543
Participants from the parent studies (80948543LYM1001 \[NCT05424822\]; and 80948543LYM1002 \[NCT06660563\]) who are deriving benefit from study treatment will continue to receive subcutaneous JNJ-80948543.
JNJ-87801493
Participants from the parent study (87801493LYM1001 \[NCT06139406\]) who are deriving benefit from study treatment will continue to receive subcutaneous JNJ-87801493 in combination with subcutaneous JNJ-80948543.
Locations (28)
Ghent University Hospital
Ghent, Belgium
Hopital Claude Huriez
Lille, France
CHU Nantes
Nantes, France
Institut Gustave Roussy
Villejuif, France
Arensia Exploratory Medicine
Tbilisi, Georgia
Alexandra Hospital
Athens, Greece
Rambam Med.Center - Hematology Institute
Haifa, Israel
Rambam Medical Center
Haifa, Israel
Hadassah University Hospita Ein Kerem
Jerusalem, Israel
National Hospital Organization Nagoya Medical Center
Nagoya, Japan
The Cancer Institute Hospital of JFCR
Tokyo, Japan
Arensia Exploratory Medicine
Chisinau, Moldova
Uniwersyteckie Centrum Kliniczne Osrodek Badan Klinicznych Wczesnych Faz
Gdansk, Poland
Pratia MCM Krakow
Krakow, Poland
Aidport Sp z o o
Skorzewo, Poland
Severance Hospital Yonsei University Health System
Seoul, South Korea
Hosp Univ Vall D Hebron 1
Barcelona, Spain
Hosp Univ Vall D Hebron
Barcelona, Spain
Hosp Univ Fund Jimenez Diaz
Madrid, Spain
Clinica Univ. de Navarra
Pamplona, Spain
Chang Kung Memorial Hospital
Kaohsiung City, Taiwan
China Medical University Hospital
Taichung, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Medical Center of Limited Liability Company Arensia Exploratory Medicine
Kyiv, Ukraine
University Hospitals Of Leicester Nhs Trust
Leicester, United Kingdom
St Bartholomews Hospital
London, United Kingdom
University Hospitals Plymouth NHS Trust
Plymouth, United Kingdom