Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
RECRUITING
NCT06793215
PHASE3

A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Sponsor: Hoffmann-La Roche

View on ClinicalTrials.gov

Summary

The purpose of this study is to evaluate the efficacy and safety of divarasib and pembrolizumab compared with pembrolizumab and pemetrexed and carboplatin or cisplatin, for the first-line treatment of adult participants with KRAS G12C-mutated, advanced or metastatic non squamous non-small cell lung cancer (NSCLC).

Official title: A Phase III, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Patients With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

600

Start Date

2025-10-24

Completion Date

2030-10-31

Last Updated

2026-03-12

Healthy Volunteers

No

Interventions

DRUG

Divarasib

Divarasib will be administered orally QD

DRUG

Pembrolizumab

Pembrolizumab will be administered via IV infusion Q3W

DRUG

Pemetrexed

Pemetrexed will be administered via IV infusion Q3W

DRUG

Carboplatin

Carboplatin will be administered via IV infusion Q3W

DRUG

Cisplatin

Cisplatin will be administered via IV infusion Q3W

Locations (195)

Alaska Oncology and Hematology

Anchorage, Alaska, United States

Marin Cancer Care Inc

Greenbrae, California, United States

Hoag Memorial Hospital

Newport Beach, California, United States

BioResearch Partner

Hialeah, Florida, United States

Ascension Sacred Heart

Pensacola, Florida, United States

Piedmont Cancer Institute, PC

Atlanta, Georgia, United States

Summit Cancer Care PC

Savannah, Georgia, United States

St. Luke's Cancer Institute

Boise, Idaho, United States

Affiliated Oncologists, LLC

Chicago Ridge, Illinois, United States

Hope and Healing Cancer Services

Hinsdale, Illinois, United States

Profound Research, LLC

Farmington Hills, Michigan, United States

Missouri Baptist Medical Center

St Louis, Missouri, United States

San Juan Oncology Associates

Farmington, New Mexico, United States

Montefiore Einstein Cancer Center

The Bronx, New York, United States

Clinical Research Alliance

Westbury, New York, United States

Firsthealth of The Carolinas

Pinehurst, North Carolina, United States

Oregon Health and Science University

Portland, Oregon, United States

St. Luke's University Health Network

Bethlehem, Pennsylvania, United States

Reading Hospital - McGlinn Cancer Institute

West Reading, Pennsylvania, United States

Baptist Cancer Center

Memphis, Tennessee, United States

Renovatio Clinical - El Paso

El Paso, Texas, United States

JPS Health Network

Fort Worth, Texas, United States

The University of Texas MD Anderson Cancer Center

Houston, Texas, United States

Community Clinical Trials

Kingwood, Texas, United States

Texas Tech Health Science Center

Lubbock, Texas, United States

Renovatio Clinical

The Woodlands, Texas, United States

University of Texas Health Center at Tyler

Tyler, Texas, United States

Virginia Oncology Associates

Norfolk, Virginia, United States

Hospital Britanico

Ciudad Autonoma Buenos Aires, Argentina

Centro Oncologico Korben

Ciudad Autonoma Buenos Aires, Argentina

Kinghorn Cancer Centre

Darlinghurst, New South Wales, Australia

Liverpool Hospital

Liverpool, New South Wales, Australia

Calvary Mater Newcastle

Waratah, New South Wales, Australia

Sunshine Coast University Hospital

Birtinya, Queensland, Australia

Royal Hobart Hospital

Hobart, Tasmania, Australia

Monash Health

Clayton, Victoria, Australia

Austin Health

Heidelberg, Victoria, Australia

Peter Maccallum Cancer Centre

Melbourne, Victoria, Australia

AZORG Campus Aalst-Moorselbaan

Aalst, Belgium

UZ Brussel

Brussels, Belgium

Cliniques Universitaires St-Luc

Brussels, Belgium

Jessa Zkh (Campus Virga Jesse)

Hasselt, Belgium

UZ Leuven Gasthuisberg

Leuven, Belgium

CHU de Liège (Sart Tilman)

Liège, Belgium

CHU HELORA - Hôpital de Mons - Site Kennedy

Mons, Belgium

AZ Delta (Campus Rumbeke)

Roeselare, Belgium

Crio - Centro Regional Integrado de Oncologia

Fortaleza, Ceará, Brazil

Centro Integrado de Oncologia de Curitiba

Curitiba, Paraná, Brazil

Liga Norte Riograndense Contra O Câncer

Natal, Rio Grande do Norte, Brazil

Irmandade Da Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Hospital Nossa Senhora da Conceicao

Porto Alegre, Rio Grande do Sul, Brazil

Fundação Pio XII Hospital de Câncer de Barretos

Barretos, São Paulo, Brazil

Instituto do Cancer do Estado de Sao Paulo - ICESP

São Paulo, São Paulo, Brazil

BC Cancer ? Kelowna (Sindi Ahluwalia Hawkins Centre)

Kelowna, British Columbia, Canada

BC Cancer - Victoria

Victoria, British Columbia, Canada

Royal Victoria Regional Health Centre

Barrie, Ontario, Canada

William Osler Health Centre - Brampton Civic Hospital

Brampton, Ontario, Canada

Jewish General Hospital

Montreal, Quebec, Canada

Centre Hospitalier Regional De Rimouski

Rimouski, Quebec, Canada

Saskatoon Cancer Centre

Saskatoon, Saskatchewan, Canada

West China Hospital - Sichuan University

Chengdu, China

Sir Run Run Shaw Hospital Zhejiang University

Hangzhou, China

Shanghai East Hospital

Shanghai, China

Shanghai Pulmonary Hospital

Shanghai, China

Aarhus Universitetshospital

Aarhus N, Denmark

Herlev Hospital, Afdeling for Kræftbehandling, Center for Kræftforskning, Klinisk Forskningsenhed

Herlev, Denmark

Rigshospitalet

København Ø, Denmark

Sjællands Universitetshospital, Roskilde

Roskilde, Denmark

Onkologisk Ambulatorium - Sønderborg

Sønderborg, Denmark

CHU Angers

Angers, France

Hopital Avicenne

Bobigny, France

Hôpital Louis Pradel, Hospices Civils de Lyon

Bron, France

Centre Francois Baclesse

Caen, France

Centre Leon Berard

Lyon, France

CHU Montpellier

Montpellier, France

Centre Antoine Lacassagne

Nice, France

Groupe Hospitalier Paris Saint Joseph

Paris, France

Hopital Tenon

Paris, France

CHU Bordeaux

Pessac, France

Centre Hospitalier Universitaire de Reims

Reims, France

CH de Saint Quentin

Saint-Quentin, France

CHU Strasbourg - Nouvel Hopital Civil

Strasbourg, France

Centre Hospitalier Bretagne Atlantique Vannes

Vannes, France

Vivantes - Klinikum Im Friedrichshain;Innere Medizin ? Hämatologie, Onkologie und Palliativmedizin

Berlin, Germany

Charite - Universitätsmedizin Berlin

Berlin, Germany

Technische Universität Dresden - Medizinische Fakultät Carl Gustav Carus;Medizinische Klinik und Poliklinik I

Dresden, Germany

KEM/Evang. Kliniken Essen Mitte gGmbH

Essen, Germany

Universitätsklinikum Essen

Essen, Germany

Klinikum Esslingen

Esslingen am Neckar, Germany

Asklepios Fachkliniken GmbH

Gauting, Germany

Krankenhaus Martha-Maria Halle-Doelau gGmbH

Halle, Germany

Universitätsklinikum Hamburg-Eppendorf

Hamburg, Germany

KRH Klinikum Siloah-Oststadt-Heidehaus

Hanover, Germany

Universität Des Saarlandes

Homburg, Germany

Lungenfachklinik Immenhausen

Immenhausen, Germany

Vincentius-Diakonissen-Kliniken gAG

Karlsruhe, Germany

SLK Kliniken Heilbronn GmbH, Standort Fachklinik Löwenstein

Löwenstein, Germany

Universität Mannheim

Mannheim, Germany

Pius Hospital Oldenburg

Oldenburg, Germany

Universitätsklinikum Regensburg

Regensburg, Germany

Klinikum Würzburg Mitte gGmbH

Würzburg, Germany

Sotiria General Hospital of Athens

Athens, Greece

Alexandras Hospital

Athens, Greece

Errikos Dynan Hospital

Athens, Greece

University Hospital of Larissa

Larissa, Greece

Interbalkan Medical Center of Thessaloniki

Thessaloniki, Greece

Theageneion Anticancer Hospital

Thessaloniki, Greece

Ag. Loukas Hospital

Thessaloniki, Greece

Queen Mary Hospital

Hong Kong, Hong Kong

Tuen Mun Hospital

Hong Kong, Hong Kong

Queen Elizabeth Hospital Department of Clinical Oncology

Kowloon, Hong Kong

Prince of Wales Hosp

Shatin, Hong Kong

Matrai Gyogyintezet

Mátraháza, Hungary

Református Pulmonológiai Centrum

Törökbálint, Hungary

St James Hospital

Dublin, Ireland

Beaumont Hospital

Dublin, Ireland

Tallaght Hospital

Dublin, Ireland

Mater Misecordiae University Hospital

Dublin, Ireland

Ospedale Giuseppe Moscati

Statte, Apulia, Italy

AORN Ospedali dei Colli Ospedale Monaldi

Naples, Campania, Italy

Istituto Nazionale Tumori Fondazione G. Pascale

Naples, Campania, Italy

A.O. Universitaria Policlinico Di Modena

Modena, Emilia-Romagna, Italy

Presidio san salvatore muraglia

Pesaro, Emilia-Romagna, Italy

Irccs Centro Di Riferimento Oncologico (CRO)

Aviano, Friuli Venezia Giulia, Italy

Azienda Ospedaliera San Camillo Forlanini

Rome, Lazio, Italy

Policlinico Universitario "Agostino Gemelli"

Rome, Lazio, Italy

IEO Istituto Europeo di Oncologia

Milan, Lombardy, Italy

Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda)

Milan, Lombardy, Italy

Humanitas Centro Catanese Di Oncologia

Misterbianco (CT), Sicily, Italy

USL 6 Toscana Nord Ovest ? P.O. Livorno

Livorno, Tuscany, Italy

Ospedale P. Pederzoli Casa di cura Privata

Peschiera Del Garda (VR), Veneto, Italy

Kyushu University Hospital

Fukuoka, Japan

The Cancer Institute Hospital of JFCR

Tokyo, Japan

ARKE Estudios Clínicos S.A. de C.V.

Mexico City, Mexico

Ziekenhuis Rijnstate

Arnhem, Netherlands

Amphia Ziekenhuis

Breda, Netherlands

Ziekenhuis St. Jansdal

Harderwijk, Netherlands

Isala

Zwolle, Netherlands

Harbour Cancer and Wellness

Auckland, New Zealand

Centrum Pulmonologii i Torakochirurgii

Bystra, Poland

Uniwersyteckie Centrum Kliniczne

Gda?sk, Poland

Krakowski Szpital Specjalistyczny im sw.Jana Pawla II

Krakow, Poland

Uniwersytecki Szpital Kliniczny nr 4 w Lublinie

Lublin, Poland

Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie

Olsztyn, Poland

Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu

Poznan, Poland

Radomskie Centrum Onkologii

Radom, Poland

Instytut Gruzlicy I Chorob Pluc

Warsaw, Poland

Mazowiecki Szpital Onkologiczny

Wieliszew, Poland

Dolnoslaskie Centrum Chorob Pluc

Wroclaw, Poland

Hospital de Braga

Braga, Portugal

Hospital Beatriz Angelo

Loures, Portugal

IPO do Porto

Porto, Portugal

CHVNG/E_Unidade 1

Vila Nova de Gaia, Portugal

National University Hospital

Singapore, Singapore

National Cancer Centre

Singapore, Singapore

Wits Donald Gordon Clinical Trial Centre

Parktown, South Africa

Chris Hani Baragwanath Clinical Trial Site

Soweto, South Africa

Pusan National University Hospital

Busan, South Korea

Chungbuk National University Hospital

Cheongju-si, South Korea

Kyungpook National University Chilgok Hospital

Daegu, South Korea

The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, South Korea

Seoul National University Hospital

Seoul, South Korea

Korea University Guro Hospital

Seoul, South Korea

Hospital Universitario Son Espases

Palma de Mallorca, Balearic Islands, Spain

Hospital Universitario Marques de Valdecilla

Santander, Cantabria, Spain

Clinica Universitaria de Navarra

Pamplona, Navarre, Spain

Vall d'Hebron Institute of Oncology (VHIO), Barcelona

Barcelona, Spain

Hospital Clinic Barcelona

Barcelona, Spain

Hospital de la Santa Creu i Sant Pau

Barcelona, Spain

Clinica Universidad de Navarra Madrid

Madrid, Spain

Hospital Ramon y Cajal

Madrid, Spain

Hospital Universitario 12 de Octubre

Madrid, Spain

Hospital Universitario La Paz

Madrid, Spain

Hospital Clinico Universitario Virgen de la Victoria

Málaga, Spain

Hospital Universitario Virgen Macarena

Seville, Spain

Hospital Clínico Universitario de Valencia

Valencia, Spain

Universitaetsspital Basel

Basel, Switzerland

Kantonsspital Graubünden Medizin Onkologie

Chur, Switzerland

Hôpital Universitaire de Genève (HUG)

Geneva, Switzerland

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, Taiwan

E-DA Hospital

Kaohsiung City, Taiwan

Chung Shan Medical University Hospital

Taichung, Taiwan

National Taiwan University Hospital

Taipei, Taiwan

Taipei Medical University Hospital

Taipei, Taiwan

Taipei Veterans General Hospital

Taipei, Taiwan

National Taiwan University Cancer Center

Zhongzheng Dist., Taiwan

Blackpool Teaching Hospitals NHS Foundation Trust , Victoria Hospital

Blackpool, United Kingdom

Bristol Haematology & Oncology Centre

Bristol, United Kingdom

East Kent Hospitals University NHS Foundation Trust

Canterbury, United Kingdom

Velindre NHS Trust - Velindre Cancer Centre

Cardiff, United Kingdom

Barts and the London NHS Trust

London, United Kingdom

Royal Marsden Hospital - Fulham

London, United Kingdom

Sarah Cannon Research Institute

London, United Kingdom

Maidstone and Tunbridge Wells NHS Trust

Maidstone, United Kingdom

Royal Marsden NHS Foundation Trust

Sutton, United Kingdom