Clinical Research Directory

Inclusion Criteria: * Male or female 18-65 years of age at time of SCI. * English speaking * Recent SCI (within 20 weeks of injury). * Documentation of a spinal cord injury at T6 or higher, American Spinal Injury Association Impairment Scale (AIS) level A or B as designated on initial (72 hour) AIS exam. * Ability for subject to comply with the requirements of the study. * Written informed consent obtained from subject. Exclusion Criteria: * Inability to return to research site (Harborview Medical Center) for follow-up studies after initial hospitalization. * Acute (as part of concurrent hospitalization) or history of bladder surgery (urethral or prostate surgery acceptable) or injury. * Inability to provide informed consent. * Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study. * Incarcerated in a detention facility or in police custody. * Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data. * Active medical problems precluding the safe conduct of urodynamics, bladder chemodenervation, bladder biopsy (e.g., evidence of active bladder infection, ruled out by urine culture prior to procedures) * Known hypersensitivity to any botulinum toxin preparation or to any of the components in the formulation * Cardiovascular instability