Clinical Research Directory
Browse clinical research sites, groups, and studies.
cGMP: Metabolism and Appetite Modulation
Sponsor: Universidade Nova de Lisboa
Summary
Phenylketonuria is an inborn error of phenylalanine metabolism. Although the phenylalanine-restricted diet is recognized as the mainstay of therapy, little is known about the impact of protein substitutes on the metabolism of patients with phenylketonuria. Therefore, the aim of this project is to study the impact of acute ingestion of casein glycomacropeptide supplemented with amino acids (cCGMP-AAs) alone or in combination with two different meals on amino acid absorption kinetics, glycaemic and insulinemic response, and on acute markers of appetite control. The main findings of this project will bring new insights into the dietary management of these patients, which may lead to improvements in protein substitutes formulations.
Official title: Metabolic Effects of cGMP: From Amino Acid Absorption Kinetics to Appetite Modulation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2025-02-03
Completion Date
2025-04-24
Last Updated
2025-01-27
Healthy Volunteers
Yes
Conditions
Interventions
cGMP-AAs alone (20 g of protein equivalent)
cGMP-AAs alone (20 g of protein equivalent)
cGMP-AAs (20 g of protein equivalent) + 50 g of low-protein bread + 160 g of unpeeled apple
cGMP-AAs (20 g of protein equivalent) + 50 g of low-protein bread + 160 g of unpeeled apple
cGMP-AAs (20 g of protein equivalent) + 50 g of low-protein bread + 10 g of olive oil
cGMP-AAs (20 g of protein equivalent) + 50 g of low-protein bread + 10 g of olive oil
Locations (1)
NOVA Medical School|Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa,
Lisbon, Portugal