Clinical Research Directory

Inclusion Criteria: * Patients over 18 years old, * Patients with CLI according international definition: 1) rest pain of ischemic origin or ischemic trophic disorder present for at least 15 days, and 2) an ankle pressure ≤50 mmHg (≤70 mmHg for diabetic patients) or a toe pressure ≤30 mmHg or a TcPO2 ≤30 mmHg, * Patient not revascularizable by decision of the surgeon or anesthesiologist orpatient with persistent critical ischemia after revascularization, * Patient with a life expectancy greater than 6 months, * Patients who signed the informed consent, * Women of childbearing age with effective contraception (oral contraception, IUD, dermal implant) and with negative pregnancy test, * Patient affiliated to a social security system. Exclusion Criteria: * Need of a major amputation (amputation at or above the ankle) within 1 month following the inclusion, * Another clinical trial participation (except observational studies), * Patient with active cancer history in the 5 previous years except cured basal cell carcinoma or cured low-stage melanoma, * Patient allergic to local anesthetics * Immunosuppressive therapy * Ulcers with exposure of tendons, osteomyelitis, or clinically uncontrolled infection, * Patient under the protection of justice or under guardianship or curatorship.