Clinical Research Directory

Inclusion Criteria: Inclusion Criteria for healthy subjects: * Male or female, aged \>=18 years. * Fully understand the nature, significance, possible benefits, possible inconveniences or potential risks of this research, and should also understand the research procedures, be willing to complete the entire research process, and provide written consent form. Inclusion Criteria for patients with type 2 diabetes: * Male or female, aged \>=18 years. * Previously diagnosed type 2 diabetes according to WHO criteria of 1999. * Fully understand the nature, significance, possible benefits, possible inconveniences or potential risks of this research, and should also understand the research procedures, be willing to complete the entire research process, and provide written consent form. Exclusion Criteria: Exclusion Criteria for healthy subjects: * There are injuries, scars, obvious pigmentation and other factors that interfere with the detection of the palm skin to be tested. * Allergy to lasers. * Had diabetes history or fasting blood glucose (FPG) \>= 6.1 mmol/L or glycated hemoglobin (HbA1c) \>= 5.7% during the screening period. * Alcohol dependency or drug abuse. * Those who have participated in clinical trials of other drugs within 3 months before screening (since the last visit of the previous trial). * Pregnancy or lactation period. * Difficulty in venous blood collection or fainting of needles or blood. * Other circumstances that the investigator considers inappropriate to participate in the study. Exclusion Criteria for patients with type 2 diabetes: * There are injuries, scars, obvious pigmentation and other factors that interfere with the detection of the palm skin to be tested. * Allergy to lasers. * Type 1 diabetes, monogenic mutant diabetes, pancreatic damage, or secondary diabetes of other causes should be excluded. * Severe structural heart disease, such as congenital heart disease, rheumatic heart disease, hypertrophic or dilated cardiomyopathy, chronic congestive heart failure (NYHA≥III); acute myocardial infarction within 12 months before enrollment; history of severe liver or kidney dysfunction (eGFR \< 60 ml/min/1.73m2 calculated by MDRD formula at screening period); and mental disorders, etc. * With a history of acute complications of diabetes within 3 months before enrollment; or severe diabetes-related complications. * Alcohol dependency or drug abuse. * Those who have participated in clinical trials of other drugs within 3 months before screening (since the last visit of the previous trial). * Pregnancy or lactation period. * Difficulty in venous blood collection or fainting of needles or blood. * Other circumstances that the investigator considers inappropriate to participate in the study.