Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study of TAK-411 in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
Sponsor: Takeda
Summary
CIDP is an autoimmune disease. This means that the body's germ fighting (immune) system attacks itself. In CIDP, the immune system attacks the protective covering around the nerves called myelin. Over time, these nerves lose their ability to send signals to the muscles in the body. This leads to muscle weakness and loss of sensation in arms and legs among other symptoms. Participants with CIDP can be treated with a protein called immunoglobulin (or IG). TAK-411 is a special type of immune globulin G (hsIgG) that has been chemically changed. It is made from IG that comes from human plasma. This study will test if TAK-411 can decrease inflammation and improve symptoms of CIDP. The main aim of this study is to check how TAK-411 affects the physical functioning of adults with CIDP when compared with results of the placebo group of a historical trial. Participants may be treated with TAK-411 for up to 1 year (51 weeks) and will be followed up for 3 weeks after last dose. During the study, participants may visit their study clinic up to approximately 21 times.
Official title: A Phase 2, Open-label, Proof-of-Concept Study to Investigate the Efficacy, Safety, and Tolerability of TAK-411 in Adult Subjects With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (The CASCA Study)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
36
Start Date
2025-05-14
Completion Date
2028-06-08
Last Updated
2026-02-13
Healthy Volunteers
No
Interventions
TAK-411
TAK-411 IV infusion.
Locations (20)
University of California San Diego
La Jolla, California, United States
California Pacific Medical Center
San Francisco, California, United States
UF Health Neurology - Jacksonville
Jacksonville, Florida, United States
Visionary Investigators Network
Miami, Florida, United States
University of South Florida
Tampa, Florida, United States
Emory University
Atlanta, Georgia, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Mayo Clinic Rochester
Rochester, Minnesota, United States
The Curators of the University of Missouri on behalf of University of Missouri Health Care
Columbia, Missouri, United States
The Washington University
St Louis, Missouri, United States
Penn Blood Disorders Program - Hospital of The University of Pennsylvania
Philadelphia, Pennsylvania, United States
Houston Methodist Research Institute
Houston, Texas, United States
University of Washington
Seattle, Washington, United States
University of Calgary
Calgary, Alberta, Canada
University Health Network
Toronto, Ontario, Canada
Neuro ClinicaS.A.S
Medellín, Antioquia, Colombia
Hospital Universitario San Ignacio
Bogotá, D.C., Colombia
Fundacion Valle del Lili
Cali, Valle del Cauca Department, Colombia
Universidad del Rosario
Bogotá, Colombia
Fundacion Oftalmologica de Santander - FOSCAL
Bucaramanga, Colombia