Clinical Research Directory

Inclusion Criteria: * 1.fulfilling ICHD-3 criteria for migraine 2. migraine for at least 3 months. Exclusion Criteria: brain imaging showing structural brain lesions. .medications that could impact autonomic function such as tricyclic antidepressants, anticholinergics, or opioids. * Patients with concomitant medical illness causing autonomic dysfunction such as: diabetes, cardiovascular, demyelinating or degenerative neurological disorders. * Contraindications for performing the tilt test * Pregnant patients.