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Motor Cortex Plasticity Response to Theta-Burst Stimulation After Ketone Monoester Supplementation
Sponsor: Universiti Putra Malaysia
Summary
Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols. Among these, intermittent- and continuous-theta burst stimulation (iTBS/cTBS) are increasingly used protocols to enhance or suppress M1 excitability, respectively, beyond stimulation. However, the poor reproducibility and high inter-individual variability in responses to TBS protocols are matters of concern. This study will explore whether ketone monoester supplementation can boost TBS efficacy via their mechanistic convergence on Brain-Derived Neurotrophic Factor (BDNF).
Official title: Priming Effects of Ketone Monoester Supplementation on Theta-Burst Stimulation-Induced Plasticity in the Primary Motor Cortex
Key Details
Gender
All
Age Range
18 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2024-12-18
Completion Date
2025-12-01
Last Updated
2025-06-25
Healthy Volunteers
Yes
Conditions
Interventions
Ketone Monoester (KME)
500 mg/kg body weight of the KME supplement
Placebo
Taste-matched placebo drink
iTBS
iTBS stimulation will be applied using a butterfly figure-of-eight Cool-B70 coil connected to a MagPro R30 stimulator with add-on Theta Burst option (MagVenture A/S, Farum, Denmark).
cTBS
cTBS stimulation will be applied using a butterfly figure-of-eight Cool-B70 coil connected to a MagPro R30 stimulator with add-on Theta Burst option (MagVenture A/S, Farum, Denmark).
Locations (1)
Hospital Sultan Abdul Aziz Shah
Serdang, Selangor, Malaysia