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Prognostic Role of molEcular classiFication in Fertility-sparing treAtment of Endometrial canCEr
Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Summary
Endometrial cancer, the most common gynecologic malignancy in high-income countries, is increasing among reproductive-age women. While hysterectomy prevents pregnancy, hormonal therapies offer fertility-sparing options for select early-stage cases, with \~80% achieving complete response (CR). Molecular classifications (POLEmut, p53abn, MMRd/MSI-H, NSMP) reveal subtype-specific prognostic differences, with NSMP showing higher CR rates and lower recurrence, while p53abn and MMRd/MSI-H fare worse. Recent studies emphasize molecular profiling's potential to guide personalized fertility-sparing treatments. This study explores the prognostic role of these classifications in treatment outcomes.
Official title: Prognostic Role of molEcular classiFication in Fertility-sparing treAtment of Endometrial canCEr: PREFACE Study
Key Details
Gender
FEMALE
Age Range
18 Years - 50 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2026-01-01
Completion Date
2028-01-31
Last Updated
2025-12-23
Healthy Volunteers
No
Conditions
Interventions
Observation only
Only observation following standard of care (histological diagnosis, molecular classification, progestine therapy)
Locations (1)
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano
Milan, Michigan, Italy