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Orexin Gene in Anorexia Nervosa
Sponsor: Istituto Auxologico Italiano
Summary
The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (\> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate the relationship of promoter methylation of the genes for OX-A and OX-B with the severity of the eating disorder, psychiatric comorbidities (in particular, depression), and sleep quality.
Official title: The Methylation Level of the Orexin Gene in Anorexia Nervosa: Relationship With Eating Disorder, Depressive State, and Sleep Quality
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2024-06-19
Completion Date
2026-06-30
Last Updated
2026-03-30
Healthy Volunteers
Yes
Conditions
Interventions
Blood samples and Questionnaires
Blood samples for methylation of the promoter of the OX-A and OX-B genes and questionnaires: Eating Disorder Examination Q Eating Disorder Inventory 3 Major Depression Inventory Symptom Checklist-revised ESS - Epworth Sleepiness Scale Pittsburgh Sleep Quality Index Horne \& Ostberg questionnaire
Locations (1)
Istituto Auxologico Italiano IRCCS, Site Piancavallo
Oggebbio, Verbania, Italy