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ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Distal Cholangiocarcinoma, and Ampullary Cancer
Sponsor: Insel Gruppe AG, University Hospital Bern
Summary
The goal of this clinical trial is to learn if total removal of the pancreas is a preferable alternative to partial removal in patients with cancer of the pancreatic head who are at high risk of pancreatic leakage. The main question it aims to answer is: Does total pancreas removal improve survival without reducing quality of life compared to partial removal? The only study specific procedures are the collection of 2 blood samples (7.5ml for each time point, preoperatively and during the hospitalisation) and the completion of the questionnaires.
Official title: ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Distal Cholangiocarcinoma, and Ampullary Cancer: a Multi-centric Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
170
Start Date
2025-05-12
Completion Date
2029-07
Last Updated
2025-09-30
Healthy Volunteers
No
Conditions
Interventions
Total pancreatectomy (TP)
The investigators perform TP in patients who undergo surgical resection of a malignant tumor in the pancreatic head.
Partial pancreaticoduodenectomy (PD)
The investigators perform partial PD with anastomosis of the pancreas in patients who undergo surgical resection of a malignant tumor in the pancreatic head. This is the current standard procedure.
Locations (7)
Department of Surgery, Kantonsspital Baden
Baden, Switzerland
Department of Visceral Surgery, University Hospital Basel
Basel, Switzerland
Inselspital, Bern University Hospital
Bern, Switzerland
Department of Visceral Surgery, University Hospital Geneva
Geneva, Switzerland
Department of General, Visceral, Endocrine and Transplantation Surgery, Kantonsspital St. Gallen
Sankt Gallen, Switzerland
Department of Surgery, Stadtspital Triemli Zürich
Zurich, Switzerland
Department of Surgery and Transplantation, University Hospital Zürich
Zurich, Switzerland